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目的：通过与典型发育（typically developing,TD）儿童进行对比，基于功能性近红外光谱（functional near-infrared spectroscopy,f NIRS）脑成像技术探究孤独症（autism spectrum disorder,ASD）伴运动功能障碍（motor dysfunction,MD）儿童静息态脑功能连接特征。方法：根据纳入和排除标准，共32名伴有MD的ASD儿童纳入ASD组，28名TD儿童纳入TD组。采用MABC-2进行运动功能评估，利用f NIRS设备采集静息状态下的脑神经活动数据，并基于皮尔逊相关性分析方法对2组儿童运动相关脑区短程和长程功能连接强度进行比较。结果：与TD组相比，ASD组MABC-2总分及3类测试项目（手部灵巧性、手眼协调能力和动静态平衡能力）得分均显著下降（P<0.05）；全脑平均功能连接强度以及短程和长程功能连接强度均显著下降（P<0.05），且差异连接的关联脑区主要为背外侧前额叶皮层（dorsolateral prefrontal cortex,DLPFC）、前运动皮层和辅助运动皮层（pre-motor and supplementary motor cortex,PMC&SMA）；相关分析发现，ASD组总体运动能力与R-PMC&SMA短程功能连接（r=0.354,P<0.05）及R-DLPFC—R-PMC&SMA(r=0.460,P<0.01)长程功能连接之间存在显著正相关关系，手眼协调能力与R-PMC&SMA短程功能连接之间存在显著正相关关系（r=0.437,P<0.05）。结论：与同年龄段TD组儿童相比，ASD组动作技能发展水平较低，静息态脑功能连接强度较弱，脑区间信息整合能力下降，且异常连接主要与DLPFC和PMC&SMA脑区有关，这可能是导致ASD儿童协调能力不足等MD发生的潜在原因。
Abstract：Objective: To investigate the resting-state functional connectivity(RSFC) characteristics of children with autism spectrum disorder(ASD) accompanied by motor dysfunction(MD) based on a functional near-infrared spectroscopy(fNIRS) brain imaging technique by comparing them with typically developing(TD) children. Methods: According to the inclusion and exclusion criteria, 32 children with ASD accompanied by MD were randomly recruited into the ASD group, and 28 children with TD into the TD group. Motor function was assessed using MABC-2 and resting-state brain neural activity data were collected via fNIRS device. The strengths of shortand long-range functional connectivity in motor-related brain regions of the two groups were compared based on the Pearson's correlation analysis method. Results: Compared with the TD group, the ASD group exhibited significantly lower total MABC-2 score and scores of three test items(manual dexterity, hand-eye coordination, static and dynamic balance)(P<0.05); the mean whole-brain functional connectivity strength, as well as the short-and long-range functional connectivity strengths decreased significantly(P<0.05), and the differential connectivity associated brain regions were mainly the dorsolateral prefrontal cortex(DLPFC), and premotor cortex and supplementary motor cortex(PMC&SMA); correlation analyses revealed significant positive correlations between the overall motor ability and the short-range functional connectivity of R-PMC&SMA(r=0.354, P<0.05) and the long-range functional connectivity of R-DLPFC—R-PMC&SMA(r=0.460, P<0.01) in the ASD group. In addition, hand-eye coordination was positively correlated with short-range functional connectivity of R-PMC&SMA(r=0.437, P<0.05). Conclusions: Compared with the age-matched TD group, the ASD group presented poorer motor skill development, decreased resting-state brain functional connectivity and impaired interregional information integration. Abnormal connectivity was mainly related to the DLPFC and PMC&SMA, which may constitute MD such as coordination deficits in children with ASD.
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基本信息:
DOI：10.16470/j.csst.2026031
中图分类号:G804.2;G76;R749.94
引用信息:
[1]董贵俊,江慧兰,李可峰,等.孤独症伴运动功能障碍儿童静息态fNIRS脑功能连接特征分析[J].中国体育科技().DOI:10.16470/j.csst.2026031.
基金信息:
教育部人文社会科学规划基金项目（25YJAZH086）; 衢州市竞争性科技攻关项目（2023K239）; 衢州市科技局指导性项目（AF/SC-08/03）
2026-10-30
2026-10-30
2026-10-30